Phage therapy against multiresistant bacteria

Authors

DOI:

https://doi.org/10.59471/ijhsc202491

Keywords:

Bacteriophage, Therapy, Phage Therapy, Bacteriophage Therapy

Abstract

Phage therapy is a promising therapeutic strategy in the treatment of bacterial infections, especially those resistant to antibiotics. It consists of the use of bacteriophages, viruses that selectively infect and destroy bacteria. Bacteriophages can replicate within pathogenic bacteria, offering a precise alternative to conventional antibiotics. It has shown encouraging results in preclinical and clinical studies, showing efficacy in infections unresponsive to antibiotics. Bacteriophages can be customized to target specific bacterial strains, allowing for an individualized approach to treatment. Although there are challenges and limitations, significant advances are being made in this field. More research and regulation is required for its development and wider adoption. Phage therapy offers real hope in the treatment of bacterial infections, but its potential impact on public health needs further investigation.

References

Oromí Durich J. Resistencia bacteriana a los antibióticos. Med Integral. 1 de diciembre de 2000;36(10):367-70.

www.ocu.org [Internet]. [citado 17 de junio de 2023]. Qué son los bacteriófagos | OCU. Disponible en: https://www.ocu.org/alimentacion/seguridad-alimentaria/informe/bacteriofagos

Liu D, Van Belleghem JD, de Vries CR, Burgener E, Chen Q, Manasherob R, et al. The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies. Viruses. 29 de junio de 2021;13(7):1268.

Iranzo M. Bacteriófagos: los «homicidas» de las bacterias. | Blog de Biotecnología by María Iranzo [Internet]. María Iranzo Biotecnología. 2020 [citado 17 de junio de 2023]. Disponible en: https://www.mariairanzobiotec.com/bacteriofagos-virus-homicidas-de-bacterias/

Prada-Peñaranda C, Holguin-Moreno AV, González-Barrios AF, Vives-Florez MJ. Fagoterapia, alternativa para el control de las infecciones bacterianas. Perspectivas en Colombia. Univ Sci. 14 de agosto de 2014;20(1):43.

Letkiewicz S, Łusiak-Szelachowska M, Międzybrodzki R, Żaczek M, Weber-Dąbrowska B, Górski A. Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections. Antibiotics. 25 de mayo de 2021;10(6):627.

Xu HM, Xu WM, Zhang L. Current Status of Phage Therapy against Infectious Diseases t5and Potential Application beyond Infectious Diseases. Int J Clin Pract. 3 de octubre de 2022;2022:4913146.

Wu N, Dai J, Guo M, Li J, Zhou X, Li F, et al. Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients. Emerg Microbes Infect. 10(1):612-8.

Petrovic Fabijan A, Lin RCY, Ho J, Maddocks S, Ben Zakour NL, Iredell JR, et al. Safety of bacteriophage therapy in severe Staphylococcus aureus infection. Nat Microbiol. marzo de 2020;5(3):465-72.

Fedorov E, Samokhin A, Kozlova Y, Kretien S, Sheraliev T, Morozova V, et al. Short-Term Outcomes of Phage-Antibiotic Combination Treatment in Adult Patients with Periprosthetic Hip Joint Infection. Viruses. 10 de febrero de 2023;15(2):499.

Carvalho CM, Gannon BW, Halfhide DE, Santos SB, Hayes CM, Roe JM, et al. The in vivo efficacy of two administration routes of a phage cocktail to reduce numbers of Campylobacter coli and Campylobacter jejuni in chickens. BMC Microbiol. 1 de septiembre de 2010;10(1):232.

Kifelew LG, Warner MS, Morales S, Vaughan L, Woodman R, Fitridge R, et al. Efficacy of phage cocktail AB-SA01 therapy in diabetic mouse wound infections caused by multidrug-resistant Staphylococcus aureus. BMC Microbiol. 9 de julio de 2020;20(1):204.

Varela-Ortiz DF, Barboza-Corona JE, González-Marrero J, León-Galván MF, Valencia-Posadas M, Lechuga-Arana AA, et al. Antibiotic susceptibility of Staphylococcus aureus isolated from subclinical bovine mastitis cases and in vitro efficacy of bacteriophage. Vet Res Commun. septiembre de 2018;42(3):243-50.

Thanki AM, Mignard G, Atterbury RJ, Barrow P, Millard AD, Clokie MRJ. Prophylactic Delivery of a Bacteriophage Cocktail in Feed Significantly Reduces Salmonella Colonization in Pigs. Microbiol Spectr. 29 de junio de 2022;10(3):e0042222.

Kosznik-Kwaśnicka K, Podlacha M, Grabowski Ł, Stasiłojć M, Nowak-Zaleska A, Ciemińska K, et al. Biological aspects of phage therapy versus antibiotics against Salmonella enterica serovar Typhimurium infection of chickens. Front Cell Infect Microbiol. 4 de agosto de 2022;12:941867.

Dufour N, Delattre R, Chevallereau A, Ricard JD, Debarbieux L. Phage Therapy of Pneumonia Is Not Associated with an Overstimulation of the Inflammatory Response Compared to Antibiotic Treatment in Mice. Antimicrob Agents Chemother. 25 de julio de 2019;63(8):e00379-19.

Teng F, Xiong X, Zhang S, Li G, Wang R, Zhang L, et al. Efficacy Assessment of Phage Therapy in Treating Staphylococcus aureus-Induced Mastitis in Mice. Viruses. 16 de marzo de 2022;14(3):620.

Reina J, Reina N. Fagoterapia ¿una alternativa a la antibioticoterapia? Rev Esp Quimioter. abril de 2018;31(2):101-4.

Desiree K, Mosimann S, Ebner P. Efficacy of phage therapy in pigs: systematic review and meta-analysis. J Anim Sci. 1 de julio de 2021;99(7):skab157.

Nadareishvili L, Hoyle N, Nakaidze N, Nizharadze D, Kutateladze M, Balarjishvili N, et al. Bacteriophage Therapy as a Potential Management Option for Surgical Wound Infections. Phage. 1 de septiembre de 2020;1(3):158-65.

Paul K, Merabishvili M, Hazan R, Christner M, Herden U, Gelman D, et al. Bacteriophage Rescue Therapy of a Vancomycin-Resistant Enterococcus faecium Infection in a One-Year-Old Child following a Third Liver Transplantation. Viruses. 7 de septiembre de 2021;13(9):1785.

Rivas LM, Mühlhauser M. Sinergismo fago-antimicrobiano en Pseudomonas aeruginosa: a possible approach to combating Pseudomonas aeruginosa. Rev Chil Infectol. octubre de 2014;31(5):627-627.

Serwer P, Wright ET, Lee JC. High murine blood persistence of phage T3 and suggested strategy for phage therapy. BMC Res Notes. 5 de septiembre de 2019;12:560.

Gaborieau B, Debarbieux L. The role of the animal host in the management of bacteriophage resistance during phage therapy. Curr Opin Virol. febrero de 2023;58:101290.

Johri AV, Johri P, Hoyle N, Pipia L, Nadareishvili L, Nizharadze D. Case Report: Chronic Bacterial Prostatitis Treated With Phage Therapy After Multiple Failed Antibiotic Treatments. Front Pharmacol. 10 de junio de 2021;12:692614.

Downloads

Published

2024-07-22

Issue

Section

Original

How to Cite

1.
Culqui Molina WP, Pinta Riofrio MD, Jiménez Espinosa PM, Suárez Jurado MA. Phage therapy against multiresistant bacteria. Interamerican Journal of Health Sciences [Internet]. 2024 Jul. 22 [cited 2024 Oct. 14];4:91. Available from: https://ijhsc.uai.edu.ar/index.php/ijhsc/article/view/91