The relationship between the gut microbiome and the development of Alzheimer's disease: a review

Authors

DOI:

https://doi.org/10.59471/ijhsc202490

Keywords:

Gut microbiome, Alzheimer's disease (AD), Gut-brain axis, Probiotics

Abstract

This review examines the relationship between the gut microbiome and Alzheimer's disease (AD). We found evidence that the gut microbiota may play a role in the pathogenesis of AD through inflammation and metabolite production. Early intervention strategies based on modulation of the gut microbiota could improve symptoms. Gut dysbiosis, inflammation, and the NLRP3 inflammasome appear to be involved in the disease. Modifying the gut microbiota with probiotics, prebiotics and dietary changes could have beneficial effects in AD, according to animal and human studies. More research is needed to understand the mechanisms and to evaluate the efficacy of these interventions in clinical trials. In conclusion, modification of the gut microbiome could be an effective therapeutic strategy for AD, but more research is needed for clinical implementation.

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Published

2024-07-22

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Original

How to Cite

1.
Rojas Bedon JC, Amores Altamirano MB, Cocha Lasluiza MW, González Cardona Y. The relationship between the gut microbiome and the development of Alzheimer’s disease: a review. Interamerican Journal of Health Sciences [Internet]. 2024 Jul. 22 [cited 2024 Nov. 3];4:90. Available from: https://ijhsc.uai.edu.ar/index.php/ijhsc/article/view/90