"Dental regeneration therapy using dental stem cells”

Authors

DOI:

https://doi.org/10.59471/ijhsc202486

Keywords:

dental stem cells, regenerative therapy, periodontitis, dental pulp, dentin

Abstract

INTRODUCTION: Regenerative dentistry has undergone significant advances in recent years, and stem cells of dental origin have emerged as a promising therapeutic tool in this field. AIM: To investigate the different types of stem cells of dental origin and to examine their potential application in regenerative therapy in dentistry. METHODOLOGY: A selection of articles published between 2018 and 2023 was performed using the recognized databases Scopus, PubMed, ProQuest, Redalyc, Ovid and Medline. RESULTS: Five main sources of stem cells of dental origin were identified, which have demonstrated their ability to differentiate into specialized cells of dental tissue, such as odontoblasts, osteoblasts and myocytes, which have diverse applications such as in the treatment of periodontitis, bone repair, regeneration of dental pulp after necrosis and the development of new teeth. CONCLUSION: This study contributes to broaden our knowledge of this evolving field and highlights the importance of continuing to investigate and explore the therapeutic applications of dental stem cells.

References

Miquet V. SA, Báez A. É. Células madre dentales, reparación y regeneración en pulpa. Vecimed. 2019;58(274):126–30.

Arbildo-Vega H, Cruzado-Oliva F, Infantes-Ruiz E. Dental stem cells and their application in dentistry. J Oral Res. 2020;9(3):220–33.

Ota KI. Fuel Cells: Past, Present and Future. IEEJ Trans Fundam Mater.

;128(5):329–32.

Pérez M. Las células madre o progenitoras. Libr la salud Cardiovasc del Hosp Clínico San Carlos y la Fund BBVA [Internet]. 2019;12(5):321–6. Available from: https://www.fbbva.es/microsites/salud_cardio/mult/fbbva_libroCorazon_cap35.pdf

Li B, Ouchi T, Cao Y, Zhao Z, Men Y. Dental-Derived Mesenchymal Stem Cells: State of the Art. Front Cell Dev Biol. 2021;9(June):1–19.

Chen Y, Huang H, Li G, Yu J, Fang F, Qiu W. Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine. Stem Cell Res Ther [Internet]. 2022;13(1):1–15. Available from: https://doi.org/10.1186/s13287-022-02716-3

Revisión A DE, wwwmedigraphicorgmx R, Astudillo-Ortiz E. Regeneración de la pulpa dental. Una revisión de la literatura. Regeneration of the dental pulp. A review of the literature. Rev ADM [Internet]. 2018;75(6):350–7. Available from: www.medigraphic.com/admwww.medigraphic.org.mx

Echezarreta D, Saavedra SC. Células madre en estomatología. Investig

Medicoquirúrgicas. 2019;11(3).

Tamayo Carbón AM, Escobar Vega H, Cuastumal Figueroa DK. Alcance de las células madre derivadas de tejido adiposo TT - Scope of stem cells derived from adipose tissue. Rev Cuba hematol inmunol hemoter [Internet]. 2021;37(2):e1237– e1237. Available from: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-

Hidalgo Díaz JR, Chachques JC, Paredes Cordero Á. Artículo Especial Actualidad en terapia regenerativa : Células madre embrionarias y pluripotenciales inducidas , factor de crecimiento angiogénico y terapia génica Cutting-edge trends on regenerative therapy : Induced embryonic and pluripotential stem cel. CorSalud.

;11(4):302–6.

Lee DK, Song SU. Immunomodulatory mechanisms of mesenchymal stem cells and their therapeutic applications. Cell Immunol. 2018;326(March):68–76.

Min Q, Yang L, Tian H, Tang L, Xiao Z, Shen J. Immunomodulatory Mechanism

and Potential Application of Dental Pulp-Derived Stem Cells in Immune-Mediated

Diseases. Int J Mol Sci. 2023;24(9).

Tsutsui TW. Dental pulp stem cells: Advances to applications. Stem Cells Cloning

Adv Appl. 2020;13:33–42.

Wang W, Yan M, Aarabi G, Peters U, Freytag M, Gosau M, et al. Cultivation of Cryopreserved Human Dental Pulp Stem Cells—A New Approach to Maintaining Dental Pulp Tissue. Int J Mol Sci. 2022;23(19).

Al Madhoun A, Sindhu S, Haddad D, Atari M, Ahmad R, Al-Mulla F. Dental Pulp Stem Cells Derived From Adult Human Third Molar Tooth: A Brief Review. Front Cell Dev Biol. 2021;9(October):1–20.

Staniowski T, Zawadzka-Knefel A, Skośkiewicz-Malinowska K. Therapeutic potential of dental pulp stem cells according to different transplant types. Molecules. 2021;26(24).

Xie F, He J, Chen Y, Hu Z, Qin M, Hui T. Multi-lineage differentiation and clinical application of stem cells from exfoliated deciduous teeth. Hum Cell [Internet].

;33(2):295–302. Available from: https://doi.org/10.1007/s13577-020-00323-z

Taguchi T, Yanagi Y, Yoshimaru K, Zhang XY, Matsuura T, Nakayama K, et al.

Regenerative medicine using stem cells from human exfoliated deciduous teeth

(SHED): a promising new treatment in pediatric surgery. Surg Today [Internet].

;49(4):316–22. Available from: http://dx.doi.org/10.1007/s00595-019-01783-z

Kato M, Tsunekawa S, Nakamura N, Miura-Yura E, Yamada Y, Hayashi Y, et al.

Secreted Factors from Stem Cells of Human Exfoliated Deciduous Teeth Directly

Activate Endothelial Cells to Promote All Processes of Angiogenesis. Cells.

;9(11).

Nada OA, El Backly RM. Stem Cells From the Apical Papilla (SCAP) as a Tool for

Endogenous Tissue Regeneration. Front Bioeng Biotechnol. 2018;6(July).

Yi B, Ding T, Jiang S, Gong T, Chopra H, Sha O, et al. Conversion of stem cells from apical papilla into endothelial cells by small molecules and growth factors. Stem Cell Res Ther. 2021;12(1):1–13.

Rojas Huerta BG. CITOTOXICIDAD DE UNA SOLUCIÓN DOBLE ANTIBIÓTICA MODIFICADA CON ANTIFÚNGICO SOBRE CÉLULAS MADRE DE PAPILA APICAL IN VITRO. Vol. 21, file:///C:/Users/VERA/Downloads/ASKEP_AGREGAT_ANAK_and_REMAJA_PRIN T.docx. 2020.

Sequeira DB, Oliveira AR, Seabra CM, Palma PJ, Ramos C, Figueiredo MH, et al.

Regeneration of pulp-dentin complex using human stem cells of the apical papilla:

in vivo interaction with two bioactive materials. Clin Oral Investig. 2021;25(9):5317–

Serralta-Interian A, Teresa Hernández-Sotomayor SM, Rodas-Junco BA. El futuro de la medicina está en tuboca: Las células madre de losdientes. Desde el Herb CICY [Internet]. 2022;14:32–5. Available from: http://www.cicy.mx/sitios/desde_herbario/

Kaiser CMF, Od ESP, Bosshardt C. Método de obtención de células madre de ligamento periodontal Method to obtain stem cells from the periodontal ligament.

;19–24.

Tutor C. Presentado por: Maëlys Combes Tutor/es: Martin Pérez Leal 1. 2021;

Bi R, Lyu P, Song Y, Li P, Song D, Cui C, et al. Function of dental follicle progenitor/stem cells and their potential in regenerative medicine: From mechanisms to applications. Biomolecules. 2021;11(7).

Zeitlin BD. Banking on teeth – Stem cells and the dental office. Biomed J [Internet].

;43(2):124–33. Available from: https://doi.org/10.1016/j.bj.2020.02.003

Zhang Z, Deng M, Hao M, Tang J. Stem Cell Therapy in Chronic Periodontitis: Host

Limitations and Strategies. Front Dent Med. 2022;2(January):1–9.

Hategan IE. Regeneración de tejido periodontal in vitro con células madre pluripotenciales de la pulpa dental (DPPSC) del tercer molar. 2014;131. Available from: https://www.tdx.cat/bitstream/handle/10803/392650/Tesi_ Iulia_Emilia_Hategan.pdf?sequence=6.xml

Loza Jarama DO, Ubilla Gavilanes TA, Guerrero Arreaga FG, Veas García HV.

Importancia de la medicina regenerativa en la odontología. Recimundo.

;2(Esp):197–224.

Chen FM, Gao LN, Tian BM, Zhang XY, Zhang YJ, Dong GY, et al. Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: A randomized clinical trial. Stem Cell Res Ther [Internet]. 2016;7(1):1–12. Available from: http://dx.doi.org/10.1186/s13287-016-0288-1

Francia A, Grazioli G, Maglia Á. Establecimiento e implementación de un protocolo simplificado de expansión y cultivo de Células Madre de Pulpa Dental Humana (DPSCh). Odontoestomatologia. 2021;38:1–14.

Zhao J, Zhou Y-H, Zhao Y-Q, Gao Z-R, Ouyang Z-Y, Ye Q, et al. Oral cavity- derived stem cells and preclinical models of jaw-bone defects for bone tissue engineering. Stem Cell Res Ther [Internet]. 2023;14(1):1–20. Available from: https://doi.org/10.1186/s13287-023-03265-z

Sybil D, Jain V, Mohanty S, Husain SA. Oral stem cells in intraoral bone formation.

J Oral Biosci [Internet]. 2020;62(1):36–43. Available from:

https://www.sciencedirect.com/science/article/pii/S1349007919302464

Kwack KH, Lee HW. Clinical Potential of Dental Pulp Stem Cells in Pulp Regeneration: Current Endodontic Progress and Future Perspectives. Front Cell Dev Biol. 2022;10(April):1–18.

Valenzuela-ramos MR, Barrios-sayritupac MM, Chacaltana-limaco RD. Bone regeneration in calvarial defects of NOD . CB17- Prkdc scid / J ( NOD SCID ) mice from dental pulp stem cells : a systematic review Regeneración ósea en defectos calvariales de ratones NOD . CB17- una revisión sistemática. 2022;33(2):42–53.

Ikeda E, Nakagawa M, Ogawa M, Takeo M, Tsuji T. Functional Tooth Regeneration as a Next-Generation Therapy. 2020;6(6).

Downloads

Published

2024-07-22

Issue

Section

Original

How to Cite

1.
Acurio- Cevallos SI, López- Llerena EE, Manuel Benites R, Rodríguez Fiallos CP. "Dental regeneration therapy using dental stem cells”. Interamerican Journal of Health Sciences [Internet]. 2024 Jul. 22 [cited 2024 Nov. 9];4:86. Available from: https://ijhsc.uai.edu.ar/index.php/ijhsc/article/view/86