Frequency of cervical lesion findings in Papanicolaou smears of women under 30 years of age analyzed in a pathology laboratory in the city of Rosario (Santa Fe)
DOI:
https://doi.org/10.59471/ijhsc2023156Keywords:
Cervical Dysplasia, Papanicolaou Test, Cervical NeoplasiaAbstract
Introduction: the Papanicolaou smear is a test used to observe the cells of the squamocolumnar junction of the cervical epithelium, with the aim of detecting precancerous cells and preventing progression to cervical cancer. Since its implementation as a population screening method, a decrease in cervical cancer incidence and mortality has been observed.
Objective: to describe the frequency of cervical lesion findings in PAP smears of women under 30 years of age analyzed in an anatomic pathology laboratory in the city of Rosario in the year 2022.
Method: a quantitative, observational, retrospective, cross-sectional, descriptive, retrospective study was carried out on women under 30 years of age attended between January 1 and December 31, 2022 at the anatomic pathology service of the Private Laboratory of Clinical-Surgical Pathology of Rosario. The population consisted of all women aged 18 to 30 years with samples sent during the study period. Data were collected through a secondary source comprising the database with PAP results, both electronic and on paper, the data collected were conformed by age, presence of lesions, adequacy of the sample and type of cellular lesion present.
Results: during the period analyzed 149 studies were reviewed with an overall median age of 26 years, of which 25 samples (16,8 %) presented some type of lesion, being 10 (40 %) HSIL with a median age 24,5 and 15 (60 %) LSIL with a median age 27.
Conclusions: we can conclude with the work performed that, every sixteen women under 30 years of age analyzed, one presents some type of cervical lesion, corresponding predominantly to lesions without risk of malignancy
References
Agencia de control de cáncer. (2018). Recomendaciones del Programa Provincial de Prevención del cáncer de cuello uterino sobre las pautas de tamizaje. Ministerio de la Salud de Santa Fe https://www.santafe.gov.ar/index.php/web/content/download/244709/1287131/
Akinfolarin, A. C., Olusegun, A. K., Omoladun, O., Omoniyi-Esan, G. O., & Onwundiegu, U. (2017). Age and Pattern of Pap Smear Abnormalities: Implications for Cervical Cancer Control in a Developing Country. Journal of cytology, 34(4), 208–211. https://doi.org/10.4103/JOC.JOC_199_15
Alrajjal, A., Pansare, V., Choudhury, M. S. R., Khan, M. Y. A., & Shidham, V. B. (2021). Squamous intraepithelial lesions (SIL: LSIL, HSIL, ASCUS, ASC-H, LSIL-H) of Uterine Cervix and Bethesda System. CytoJournal, 18, 16. https://doi.org/10.25259/Cytojournal_24_2021
Arrossi, S., Matos, E., Zengarini, N., Roth, B., Sankaranayananan, R. y Parkin, M. (2007). El impacto socioeconómico del cáncer cervicouterino en pacientes y sus familias en Argentina, y su influencia en el cumplimiento de la radioterapia. Resultados de un estudio transversal. Oncología ginecológica, 105(2), 335–340. https://doi.org/10.1016/j.ygyno.2006.12.010
Bedell, S. L., Goldstein, L. S., Goldstein, A. R., & Goldstein, A. T. (2020). Cervical Cancer Screening: Past, Present, and Future. Sexual Medicine Reviews, 8(1), 28–37. https://doi.org/10.1016/j.sxmr.2019.09.005
Canfell K. (2019). Towards the global elimination of cervical cancer. Papilomavirus Research 8. https://doi.org/10.1016/j.pvr.2019.100170
Dasgupta S. (2023). The Fate of Cervical Dysplastic Lesions during Pregnancy and the Impact of the Delivery Mode: A Review. Cureus, 15(7). https://doi.org/10.7759/cureus.42100 Deguara, M., Calleja, N., & England, K. (2021). Cervical cancer and screening: knowledge, awareness and attitudes of women in Malta. Journal Of Preventive Medicine and Hygiene, 61(4), 584–592. https://doi.org/10.15167/2421-4248/jpmh2020.61.4.1521
De Sousa, K., & Colmenares, E. J. (2019). Resultados cito-colpo-histológicos en lesiones del cuello uterino en pacientes en edad fértil de la consulta ginecológica del Centro Materno Pediátrico Zulia, 2015-2016. Archivos Venezolanos de Farmacología y Terapéutica, 38(6), 723-728.
Denninghoff, V., von Petery, F., Fresno, C., Galarza, M., Torres, F., Avagnina, A., Fishkel, V., Krupitzki, H., Fiorillo, A., & Monge, F. (2022). Clinical implementation of a cervical cancer screening program via co-testing at a university hospital. PloS one, 17(12). https://doi.org/10.1371/journal.pone.0278476
Diaz, G. V. (2021). Adherencia al tratamiento y seguimiento de lesiones cervicales de alto grado en mujeres del Distrito Sanitario de la provincia de Formosa. Periodo 2015 2017.
Eun, T. J. y Perkins, R. B. (2020). Pruebas de detección del cáncer de cuello uterino. Clínicas Médicas de América del Norte, 104(6), 1063–1078. 10.1016/j.mcna.2020.08.006
Ghosh, S., Shetty, R. S., Pattanshetty, S. M., Mallya, S. D., Pandey, D., Kabekkodu, S. P., Kamath, V. G., Prabhu, N., D’souza, J., & Satyamoorthy, K. (2019). Human papilloma and other DNA virus infections of the cervix: A population based comparative study among tribal and general population in India. PloS One, 14(6). https://doi.org/10.1371/journal.pone.0219173
Hashmi, A. A., Naz, S., Ahmed, O., Yaqeen, S. R., Irfan, M., Asif, M. G., Kamal, A., & Faridi, N. (2020). Comparison of Liquid-Based Cytology and Conventional Papanicolaou Smear for Cervical Cancer Screening: An Experience From Pakistan. Cureus, 12(12). https://doi.org/10.7759/cureus.12293
Instituto Nacional del Cáncer (2020). Estadísticas – Incidencia. Ministerio de la Salud de Argentina. https://www.argentina.gob.ar/salud/instituto-nacional-delcancer/estadisticas/incidencia
Ivanovich, R. C., & Calli, R. F. (2019). Inequidades en mortalidad por cáncer de mama y cuello de útero en Argentina en 2001-2016: estudio ecológico. Revista Argentina Salud Pública, 2019,10 (16-21).
Kumar V., Abbas A.K., Aster J.C (2015) Respuesta celular al estrés y las agresiones tóxicas: adaptación, lesión y muerte. En Kumar V., Abbas A.K, Aster J.C (Eds.). Robbins y Cotran Patología Estructural y Funcional (31-68). Elsevier Inc.
Kumar V., Abbas A.k., Aster J.C (2015) Características de lesiones benignas y malignas. En Kumar V., Abbas A.K, Aster J. (Eds). Robbins y Cotran Patología Estructural y Funcional (270-271) Elservier Inc.
Kuttel, V. Y. (2020). Percepciones y conocimientos de mujeres de una comunidad universitaria sobre el cáncer cervicouterino, el papanicolaou y su realización. Estudio de caso en la Universidad Nacional del Litoral. Período 2016 – 2017, Santa fe - Argentina.
Mayer, C., & Mahdy, H. (2023). Abnormal Papanicolaou Smear. In StatPearls. StatPearls Publishing. Abnormal Papanicolaou Smear - StatPearls - NCBI Bookshelf (nih.gov)
Moreno Barrios M.C (2017). Actualización en el reporte de citología cervicovaginal basado en el Sistema de Bethesda 2014. Revista de Obstetricia y Ginecología de Venezuela, 77 (1), 58-66. http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0048-77322017000100008&lng=es&tlng=es
Mulongo, M., & Chibwesha, C. J. (2022). Prevention of Cervical Cancer in Low-Resource African Settings. Obstetrics and Gynecology Clinics of North America, 49(4), 771–781. https://doi.org/10.1016/j.ogc.2022.08.008
Organización mundial de la Salud (2020). Cáncer cervicouterino. WHO. https://www.who.int/es/news-room/fact-sheets/detail/cervical-cancer
Organización mundial de la Salud (2020). Una estrategia mundial para la eliminación del cáncer cervicouterino. WHO. https://www.paho.org/es/temas/cancercervicouterino/estrategia-mundial-para-eliminacion-cancer-cervicouterino
Pangarkar M. A. (2022). The Bethesda System for reporting cervical cytology. CytoJournal, 19, 28. https://doi.org/10.25259/CMAS_03_07_2021
Paolino, M. D., Sankaranarayanan, R., & Arrossi, S. (2013). Determinantes sociales del abandono del diagnóstico y el tratamiento de mujeres con Papanicolaou anormal en Buenos Aires, Argentina. Revista Panamericana de Salud Pública, 34;6, 437-445.
Pirtea, L., Secosan, C., Margan, M., Moleriu, L., Balint, O., Grigoras, D., Sas, I., Horhat, F., Jianu, A., & Ilina, R. (2019). p16/Ki-67 dual staining has a better accuracy than human papillomavirus (HPV) testing in women with abnormal cytology under 30 years old. Bosnian journal of basic medical sciences, 19(4), 336–341. https://doi.org/10.17305/bjbms.2018.3560
Polman, N. J., Snijders, P. J. F., Kenter, G. G., Berkhof, J., & Meijer, C. J. L. M. (2019). HPVbased cervical screening: Rationale, expectations and future perspectives of the new Dutch screening programme. Preventive Medicine, 119, 108–117. https://doi.org/10.1016/j.ypmed.2018.12.021
Rajaram, S., Gupta, B. (2021). Screening for cervical cancer: Choices & dilemmas. The Indian Journal of Medical Research, 154(2), 210–220. https://doi.org/10.4103/ijmr.IJMR_857_20
Ran, Z., Wu, S., Ma, Z., Chen, X., Liu, J., & Yang, J. (2022). Advances in exosome biomarkers for cervical cancer. Cancer Medicine, 11(24), 4966–4978. https://doi.org/10.1002/cam4.4828
Rerucha, C. M., Caro, R. J., & Wheeler, V. L. (2018). Cervical Cancer Screening. American Family Physician, 97(7), 441–448. Cervical Cancer Screening | AAFP
Sawaya, G. F., Smith-McCune, K., & Kuppermann, M. (2019). Cervical Cancer Screening: More Choices in 2019. JAMA, 321(20), 2018–2019. https://doi.org/10.1001/jama.2019.4595
Smith, E. R., George, S. H., Kobetz, E., & Xu, X. X. (2018). New biological research and understanding of Papanicolaou’s test. Diagnostic Cytopathology, 46(6), 507–515. https://doi.org/10.1002/dc.23941
Tagne Simo, R., Mbock, C. V., Nwabo Kamdje, A. H., Djoko Nono, A. G., Nangue, C., & Telefo, P. B. (2023). Cervical Precancerous Lesions and Associated Factors Among Women Screened in Two Hospitals in the City of Douala, Cameroon. Cureus, 15(7). https://doi.org/10.7759/cureus.41993
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