Atomoxetine as a treatment for attention déficit hiperactivity disorder: a literature review
DOI:
https://doi.org/10.59471/ijhsc2025271Keywords:
Atomoxetine, Attention Deficit Hyperactivity Disorder, Atomoxetine Hydrochloride, Adverse Effects, EfficacyAbstract
Introduction: Attention Deficit Hyperactivity Disorder (ADHD) is an increasingly common neurobiological disorder with some therapeutic variants. Atomoxetine is a non-stimulant, potent and selective inhibitor with a tendency to be used in this condition.
Objective: to analyze the results of Atomoxetine in terms of dependence and effectiveness in the symptomatic control of Attention Deficit Hyperactivity Disorder.
Method: a search for information was carried out in the PubMed database using inclusion and exclusion criteria where 12 articles were analyzed, including case-control studies, clinical studies and randomized controlled trials.
Results: a total of 12 articles were identified, 6 of which provided substantial information on the use of Atomoxetine, effectiveness, and risk/benefit versus placebos and stimulant pharmacotherapy.
Conclusion: Atomoxetine is a safe and effective drug for the treatment of ADHD because of the low risk of dependence and side effects compared to other drugs already in use
References
López-López A, Poch-Olivé ML, López-Pisón J, Cardo Jalón E. Treatment of attention deficit Hyperactivity disorder in routine clinical practice: Retrospective study. Medicina (B. Aires) (Internet). 2019; 79(1 Suppl 1): 68-71.
Yaylacı F, Şahbudak B, Küçük Ö. Spontaneous Ejaculation Induced with Atomoxetine. Psychopharmacol Bull. 2020;50(1):40-43.
Kowalczyk OS, Cubillo AI, Criaud M, et al. Single-dose effects of methylphenidate and atomoxetine on functional connectivity during an n-back task in boys with ADHD. Psychopharmacology (Berl). 2023;240(10):2045-2060. doi:10.1007/s00213-023-06422-7
Atomoxetina en vademecum (Internet). Iqb.es. Disponible en: https://www.iqb.es/cbasicas/farma/farma04/a091.htm
Grimmsmann T, Himmel W. The 10-year trend in drug prescriptions for attention- deficit/Hyperactivity disorder (ADHD) in Germany. Eur J Clin Pharmacol. 2021;77(1):107-115. doi:10.1007/s00228-020-02948-3
Dutta CN, Christov-Moore L, Ombao H, Douglas PK. Neuroprotection in late life attention-deficit/hyperactivity disorder: A review of pharmacotherapy and phenotype across the lifespan. Front Hum Neurosci. 2022; 16:938501. doi:10.3389/fnhum.2022.938501
Kok FM, Groen Y, Fuermaier ABM, Tucha O. The female side of pharmacotherapy for ADHD- A systematic literature review. PLoS One. 2020;15(9):e0239257. doi: 10.1371/journal.pone.0239257
Cheng JY, Chen RY, Ko JS, Ng EM. Efficacy and safety of atomoxetine for attention- deficit/hyperactivity disorder in children and adolescents-meta-analysis and meta-regression analysis. Psychopharmacology (Berl). 2007;194(2):197-209. doi:10.1007/s00213-007-0840-x
Sugimoto A, Suzuki Y, Orime N, et al. The lowest effective plasma concentration of atomoxetine in pediatric patients with attention deficit/Hyperactivity disorder: A non- randomized prospective interventional study. Medicine (Baltimore). 2021;100(27):e26552. doi:10.1097/MD.0000000000026552
Purper-Ouakil D, Fourneret P, Wohl M, Rénéric JP. L'atomoxétine: un nouveau traitement du trouble déficitaire de l'attention/hyperactivité de l'enfant et de l'adolescent (Atomoxetine: a new treatment for Attention Deficit/Hyperactivity Disorder (ADHD) in children and adolescents). Encephale. 2005;31(3):337-348. doi:10.1016/s0013-7006(05)82399-1
Brunkhorst-Kanaan N, Libutzki B, Reif A, Larsson H, McNeill RV, Kittel-Schneider S. ADHD and accidents over the life span - A systematic review. Neurosci Biobehav Rev. 2021;125:582-591. doi:10.1016/j.neubiorev.2021.02.002
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Copyright (c) 2025 Stefanny Sanchez Vasquez, Marcelo Adrian Estrin (Author)
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