Drug-induced acute-stage narrow-angle glaucoma: a review of the literature

Authors

DOI:

https://doi.org/10.59471/ijhsc2025269

Keywords:

Iridocorneal Angle, Glaucoma, Inducer Drugs, Iatrogenic, Hyperopia

Abstract

Introduction: Drug-induced narrow-angle glaucoma is a significant condition for ophthalmologists and general practitioners because of its ability to cause blindness. 
Objective: describe which drugs or drug families may induce narrow-angle glaucoma.
Method: a search for information was carried out in PubMed, SciELO and Scopus, in the period 1986 - 2023 without language restrictions. Thirty-four articles were selected from a total of 60, including systematic reviews, case studies and meta-analyses.
Results: several drugs can induce narrow-angle glaucoma in susceptible individuals by different mechanisms, such as pupillary block, ciliary effusion and vitreous hemorrhage. There is no universal solution, but special vigilance in hyperopic patients and assessment of lateral anterior chamber depth are crucial. Acute symptoms may include headache, blurred vision, nausea and vomiting, with semidilated pupils and sudden visual changes as indicative signs. Urgent medical intervention is essential to preserve sight in these cases.
Conclusion: drug analysis showed that drugs such as adrenergic agonists, antidepressants, anticoagulants, cholinergic agents and other pharmacological groups were identified as a cause of drug-induced narrow angle glaucoma

References

Lachkar Y, Bouassida W. Drug-induced acute angle closure glaucoma. Curr Opin Ophthalmol. marzo de 2007;18(2):129-33.

Razeghinejad MR, Myers JS, Katz LJ. Iatrogenic glaucoma secondary to medications. Am J Med. enero de 2011;124(1):20-5.

Lai JSM, Gangwani RA. Medication-induced acute angle closure attack. Hong Kong Med J Xianggang Yi Xue Za Zhi. abril de 2012;18(2):139-45.

Berdy GJ, Berdy SS, Odin LS, Hirst LW. Angle closure glaucoma precipitated by aerosolized atropine. Arch Intern Med. agosto de 1991;151(8):1658-60.

Natesh S, Rajashekhara SK, Rao ASD, Shetty B. Topiramate-induced angle closure with acute myopia, macular striae. Oman J Ophthalmol. enero de 2010;3(1):26-8.

Flores-Sánchez BC, Tatham AJ. Acute angle closure glaucoma. Br J Hosp Med Lond Engl 2005. 2 de diciembre de 2019;80(12):C174-9.

Ah-Kee EY, Egong E, Shafi A, Lim LT, Yim JL. A review of drug-induced acute angle closure glaucoma for non-ophthalmologists. Qatar Med J. 2015;2015(1):6.

Quigley HA. Angle-closure glaucoma-simpler answers to complex mechanisms: LXVI Edward Jackson Memorial Lecture. Am J Ophthalmol. noviembre de 2009;148(5):657-669.e1.

Kavitha S, Zebardast N, Palaniswamy K, Wojciechowski R, Chan ES, Friedman DS, et al. Family history is a strong risk factor for prevalent angle closure in a South Indian population. Ophthalmology. noviembre de 2014;121(11):2091-7.

Wolfs RC, Grobbee DE, Hofman A, de Jong PT. Risk of acute angle-closure glaucoma after diagnostic mydriasis in nonselected subjects: the Rotterdam Study. Invest Ophthalmol Vis Sci. noviembre de 1997;38(12):2683-7.

Lentschener C, Ghimouz A, Bonnichon P, Parc C, Ozier Y. Acute postoperative glaucoma after nonocular surgery remains a diagnostic challenge. Anesth Analg. abril de 2002;94(4):1034- 5, table of contents.

Elliott Yann Ah-kee, Eric Egong, Ahad Shafi, Lik Thai Lim, James Li Yim. A review of drug- induced acute angle closure glaucoma for non-ophthalmologists. Qatar Med J. 2015;2015:6.

Zenzen CT, Eliott D, Balok EM, Watnick RL, German P. Acute angle-closure glaucoma associated with intranasal phenylephrine to treat epistaxis. Arch Ophthalmol Chic Ill 1960. abril de 2004;122(4):655-6.

Khan MAJ, Watt LL, Hugkulstone CE. Bilateral acute angle-closure glaucoma after use of Fenox nasal drops. Eye Lond Engl. septiembre de 2002;16(5):662-3.

Brooks AM, West RH, Gillies WE. The risks of precipitating acute angle-closure glaucoma with the clinical use of mydriatic agents. Med J Aust. 7 de julio de 1986;145(1):34-6.

Kalra L, Bone MF. The effect of nebulized bronchodilator therapy on intraocular pressures in patients with glaucoma. Chest. abril de 1988;93(4):739-41.

Zheng L, Azar D. Angle-closure glaucoma following periorbital botulinum toxin injection. Clin Experiment Ophthalmol. 2014;42(7):690-3.

Corridan P, Nightingale S, Mashoudi N, Williams AC. Acute angle-closure glaucoma following botulinum toxin injection for blepharospasm. Br J Ophthalmol. mayo de 1990;74(5):309-10.

Lachkar Y, Bouassida W. Drug-induced acute angle closure glaucoma. Curr Opin Ophthalmol. marzo de 2007;18(2):129-33.

Epstein NE, Goldbloom DS. Oral imipramine and acute angle-closure glaucoma. Arch Ophthalmol Chic Ill 1960. junio de 1995;113(6):698; author reply 699.

Ng B, Sanbrook GMC, Malouf AJ, Agarwal SA. Venlafaxine and bilateral acute angle closure glaucoma. Med J Aust. 4 de marzo de 2002;176(5):241.

Richa S, Yazbek JC. Ocular adverse effects of common psychotropic agents: a review. CNS Drugs. junio de 2010;24(6):501-26.

Wang L, Zhang X, Cai S, Ma J, Liu X, Wang N. Correlated or not: Glaucoma prevalence and modern industrialization. Med Hypotheses. febrero de 2011;76(2):220-4.

Lee GC, Tam CP, Danesh-Meyer HV, Myers JS, Katz LJ. Bilateral angle closure glaucoma induced by sulphonamide-derived medications. Clin Experiment Ophthalmol. 2007;35(1):55-8.

Panday VA, Rhee DJ. Review of sulfonamide-induced acute myopia and acute bilateral angle-closure glaucoma. Compr Ophthalmol Update. 2007;8(5):271-6.

Rhee DJ, Ramos-Esteban JC, Nipper KS. Rapid resolution of topiramate-induced angle- closure glaucoma with methylprednisolone and mannitol. Am J Ophthalmol. junio de 2006;141(6):1133-4.

Ikeda N, Ikeda T, Nagata M, Mimura O. Ciliochoroidal effusion syndrome induced by sulfa derivatives. Arch Ophthalmol Chic Ill 1960. diciembre de 2002;120(12):1775.

Spadoni VS, Pizzol MMD, Muniz CHG, Melamed J, Fortes Filho JB. [Bilateral angle-closure glaucoma induced by trimetoprim and sulfamethoxazole combination: case report]. Arq Bras Oftalmol. 2007;70(3):517-20.

Fraunfelder FW, Fraunfelder FT, Keates EU. Topiramate-associated acute, bilateral, secondary angle-closure glaucoma. Ophthalmology. enero de 2004;111(1):109-11.

Parthasarathi S, Myint K, Singh G, Mon S, Sadasivam P, Dhillon B. Bilateral acetazolamide- induced choroidal effusion following cataract surgery. Eye Lond Engl. junio de 2007;21(6):870-2.

Malagola R, Arrico L, Giannotti R, Pattavina L. Acetazolamide-induced cilio-choroidal effusion after cataract surgery: unusual posterior involvement. Drug Des Devel Ther. 2013;7:33- 6.

Schlote T, Freudenthaler N, Gelisken F. [Anticoagulative therapy in patients with exudative age-related macular degeneration: acute angle closure glaucoma after massive intraocular hemorrhage]. Ophthalmol Z Dtsch Ophthalmol Ges. noviembre de 2005;102(11):1090-6.

Pesin SR, Katz LJ, Augsburger JJ, Chien AM, Eagle RC. Acute angle-closure glaucoma from spontaneous massive hemorrhagic retinal or choroidal detachment. An updated diagnostic and therapeutic approach. Ophthalmology. enero de 1990;97(1):76-84.

Yang MC, Lin KY. Drug-induced Acute Angle-closure Glaucoma: A Review. J Curr Glaucoma Pract. diciembre de 2019;13(3):104-9

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Published

2025-01-01

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Review

How to Cite

1.
O’Ryan Araneda FE, Estrin MA. Drug-induced acute-stage narrow-angle glaucoma: a review of the literature. Interamerican Journal of Health Sciences [Internet]. 2025 Jan. 1 [cited 2024 Oct. 14];5:269. Available from: https://ijhsc.uai.edu.ar/index.php/ijhsc/article/view/269