Frequency of different histopathological varieties of cutaneous malignant neoplastic lesions diagnosed in an anatomopathological laboratory in the city of Rosario

Authors

  • Paulina Oriana Chiesa Universidad Abierta Interamericana. Santa Fe, Argentina Author

DOI:

https://doi.org/10.59471/ijhsc2025252

Keywords:

Basal Cell Carcinoma, Bowen's Disease, Melanoma, Wounds and Lesions

Abstract

Introduction: The skin, like any organ, can be affected by genetic and environmental factors, generating neoplasms or new cell formations. These can be benign, premalignant or malignant. Cutaneous malignant tumors present different histological types, which implies different prognoses and evolution. Distinguishing them is essential for adequate clinical and prognostic management. Materials and Methods: This study describes the frequency of histopathological varieties of cutaneous malignant neoplasms diagnosed in an anatomopathological laboratory in Rosario, Argentina, between 2016 and 2021. It is a quantitative, descriptive, observational, cross-sectional and retrospective study. Laboratory biopsies were analyzed, selecting those with diagnoses of cutaneous malignant neoplasms. Results and discussion: 1,320 samples from 1,288 patients with cutaneous malignant tumors were analyzed, basal cell carcinoma the most frequent variant, followed by squamous cell carcinoma, malignant melanoma and Bowen's disease. Women younger than 60 years and men older than 60 years were the most affected. Lesions were mostly on the face, thorax and head, except for malignant melanoma, which mainly affected the thorax and lower limbs. Conclusion: Cutaneous malignant neoplasms were common in the sample studied, with an average of four diagnoses per week. In contrast to international studies, the frequency of these malignant neoplasms was higher than in other countries.

References

Tsiogka A, Rubin AI, Gregoriou S, Soulaidopoulos S, Belyayeva H, Rigopoulos D. Prevalence of subungual melanoma in patients with cutaneous malignant melanoma: A systematic review and meta-analysis. J Eur Acad Dermatol Venereol JEADV 2024;38:77-83. https://doi.org/10.1111/jdv.19482.

Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, et al. Melanoma in children: A systematic review and individual patient meta-analysis. J Eur Acad Dermatol Venereol JEADV 2023;37:1758-76. https://doi.org/10.1111/jdv.19220.

Tsai SY-C, Hamilton CE, Mologousis MA, Hawryluk EB. Melanoma-like features in pediatric longitudinal melanonychia: A systematic review and meta-analysis. Pediatr Dermatol 2024;41:613-20. https://doi.org/10.1111/pde.15597.

Vitali F, Colucci R, Di Paola M, Pindo M, De Filippo C, Moretti S, et al. Early melanoma invasivity correlates with gut fungal and bacterial profiles. Br J Dermatol 2022;186:106-16. https://doi.org/10.1111/bjd.20626.

Wankhede D, Grover S. Outcomes After Curative Metastasectomy for Patients with Malignant Melanoma: A Systematic Review and Meta-analysis. Ann Surg Oncol 2022;29:3709-23. https://doi.org/10.1245/s10434-022-11351-4.

Boutros A, Tanda ET, Croce E, Catalano F, Ceppi M, Bruzzone M, et al. Activity and safety of first-line treatments for advanced melanoma: A network meta-analysis. Eur J Cancer Oxf Engl 1990 2023;188:64-79. https://doi.org/10.1016/j.ejca.2023.04.010.

Kuang T, Zhang L, Qiu Z, Zhang Y, Wang W. Prognostic value of body composition on survival outcomes in melanoma patients receiving immunotherapy. Front Immunol 2023;14:1261202. https://doi.org/10.3389/fimmu.2023.1261202.

Li Y, Liang X, Li H, Chen X. Comparative efficacy and safety of immune checkpoint inhibitors for unresectable advanced melanoma: A systematic review and network meta-analysis. Int Immunopharmacol 2023;115:109657. https://doi.org/10.1016/j.intimp.2022.109657.

Dafni U, Michielin O, Lluesma SM, Tsourti Z, Polydoropoulou V, Karlis D, et al. Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis. Ann Oncol Off J Eur Soc Med Oncol 2019;30:1902-13. https://doi.org/10.1093/annonc/mdz398.

Landi MT, Bishop DT, MacGregor S, Machiela MJ, Stratigos AJ, Ghiorzo P, et al. Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility. Nat Genet 2020;52:494-504. https://doi.org/10.1038/s41588-020-0611-8.

Vujic I, Gandini S, Stanganelli I, Fierro MT, Rappersberger K, Sibilia M, et al. A meta-analysis of melanoma risk in industrial workers. Melanoma Res 2020;30:286-96. https://doi.org/10.1097/CMR.0000000000000531.

Cho KK, Cust AE, Foo YM, Long GV, Menzies AM, Eslick GD. Metastatic acral melanoma treatment outcomes: a systematic review and meta-analysis. Melanoma Res 2021;31:482-6. https://doi.org/10.1097/CMR.0000000000000764.

De Virgilio A, Costantino A, Canzano F, Accorona R, Mercante G, Ferreli F, et al. Regional disease control in sinonasal mucosal melanoma: Systematic review and meta-analysis. Head Neck 2021;43:705-15. https://doi.org/10.1002/hed.26537.

National Cancer Institute. Cancer Stat Facts Melanoma Skin 2020. https://seer.cancer.gov/statfacts/html/melan.html.

Loria D, González A, Latorre C. Epidemiología del melanoma cutáneo en Argentina: análisis del Registro Argentino de Melanoma Cutáneo. Dermatol Argent 2010;16:39-45.

Hernández-Sampieri R, Mendoza Torres C. Metodología de la Investigación: las rutas cuantitativa, cualitativa y mixta. 1ra ed. México DF, México: McGraw Hill Education; 2019.

Ho J, Collie CJ. What’s new in dermatopathology 2023: WHO 5th edition updates. J Pathol Transl Med 2023;57:337. https://doi.org/10.4132/jptm.2023.09.22.

Asociasión Médica Mundial. Declaración de Helsinki: Investigación médica en participantes humanos. Asoc Médica Mund 2024. http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S1726-569X2000000200010&lng=en&nrm=iso&tlng=en (accedido 30 de octubre de 2024).

Senado y Cámara de Diputados de la Nación Argentina. Ley de proteccion de los datos personales. 2000.

Telich Tarriba J, Monter Plata A, Víctor Baldín A, Apellaniz Campo A. Diagnóstico y tratamiento de los tumores malignos de piel. Acta Médica Grupo Ángeles 2017;15:154-60.

Fernandez Pinilla J. Características clínicas y sociodemográficas del cáncer de piel en los pacientes atendidos en el servicio de dermatología de la clínica Chía en el año 2015 2016.

García Massó D, Cruz Setien R, Rimblas Casamor C, Menéndez Rodríguez M, Samada Durán T. Caracterización clínicoepidemiológica de pacientes con tumores epiteliales cutáneos no melanoma. Medisan 2019;23:260-70.

Gobierno de la Provincia de Buenos Aires. Inst Prov Cáncer 2021. https://www.ms.gba.gov.ar/sitios/controldecancer/.

Schwarz R, Schwarz R. Cáncer de piel no melanoma en cabeza y cuello. Rev Médica Clínica Las Condes 2018;29:445-67. https://doi.org/10.1016/j.rmclc.2018.06.007.

Downloads

Published

2025-01-01

Issue

Section

Original

How to Cite

1.
Chiesa PO. Frequency of different histopathological varieties of cutaneous malignant neoplastic lesions diagnosed in an anatomopathological laboratory in the city of Rosario. Interamerican Journal of Health Sciences [Internet]. 2025 Jan. 1 [cited 2024 Nov. 21];5:252. Available from: https://ijhsc.uai.edu.ar/index.php/ijhsc/article/view/252