Oral candidiasis: differentiation of Candida spp strains and antifungal treatments

Authors

  • Marcia Godoy Universidad Abierta Interamericana. Facultad De Medicina y Ciencias de la Salud Carrera de Odontologia Author
  • María Isabel Brusca Universidad Abierta Interamericana. Facultad De Medicina y Ciencias de la Salud Carrera de Odontologia Author

DOI:

https://doi.org/10.59471/ijhsc2025249

Keywords:

Candida, Emerging Pathogens, Antifungal Drugs, Antifungal Treatments

Abstract

Introduction: Candida spp is one of the most common yeast species within the oral cavity as a habitual commensal, which in turn is frequently found as an etiological agent of superficial infections.

Objective: to characterize aspects related to candidiasis, the acquisition of resistance and its treatment.

Method: a review of the available bibliography in databases such as SciELO, Scopus and ClinicalKey was carried out, of which a total of 19 related articles were consulted, empirical methods such as logical history and analysis and synthesis were used.

Results: resistance is not only given by the Candida species but also by factors inherent to the host such as the existence of prevalent diseases, massive systemic infections, septicemias, such as immunocompromised patients. The Candida spp species is part of the usual microbiota of living beings, they are opportunistic pathogens that have the capacity to cause superficial, skin or mucosal, or systemic infections. Antifungals used in treatment may be fungistatic or fungicidal. C. albicans predominates in the oral cavity to a greater extent. The species mentioned may be found in the oral cavity and pass into the bloodstream due to host immunodeficiency, as well as other predisposing factors.

Conclusions: currently, none of the available antifungals have the characteristics of an ideal antifungal: broad spectrum of action, fungicide, zero resistance rate, multiple administration routes, high capacity for tissue penetration, but without toxicity; and also develop a prophylactic and therapeutic action, without producing adverse effects and maintaining a high effectiveness.

References

Negroni M. Microbiología estomatológica. Fundamentos y guía práctica. BOOKS 2010. https://books.google.com.cu/books?hl=es&lr=&id=Gxmui-vjZBgC&oi=fnd&pg=PA1&dq=1-%09Negroni,+M.+Microbiolog%C3%ADa+estomatol%C3%B3gica.+Fundamentos+y+gu%C3%ADa+pr%C3%A1ctica.+Argentina&ots=QoHDlDF5kQ&sig=j0UQVHr0NoYIcZJ97jyvezH1kRU&redir_esc=y#v=onepage&q=1-%09Negroni%2C%20M.%20Microbiolog%C3%ADa%20estomatol%C3%B3gica.%20Fundamentos%20y%20gu%C3%ADa%20pr%C3%A1ctica.%20Argentina&f=false.

Riera F. Asociación Panamericana de Infectología. Infecciones fúngicas sistémicas : manual práctico.3a edición bilingüe. ApiInfectologia 2019. https://apiinfectologia.org/wp-content/uploads/2023/11/MANUAL-MICOSIS.pdf.

Salazar Vásquez M, Sacsaquispe Contreras S. Presencia de hifas de cándida en adultos con mucosa oral clínicamente saludable. Revista Estomatológica Herediana 2005. https://doi.org/file:///C:/Users/Alex/Documents/Downloads/ojsadm,+1978-3739-1-CE%20(1).pdf.

Muñoz del Valle G. Candida glabrata Un patógeno emergente. Dialnet 2015;10. https://dialnet.unirioja.es/servlet/articulo?codigo=5460373.

Navarrete Cuadrado K, Estrada J, Salinas H, Bolaño Cervantes M. Infección nosocomial por Candida haemulonii en un lactante mayor. Dialnet 2020;15. https://dialnet.unirioja.es/servlet/articulo?codigo=8456850.

Santo Guanoluisa JM, Ron Mora ÁS. Bacterial resistance of microbial agents causing urinary tract infections in pregnant women. Salud, Ciencia y Tecnología 2024;4:728. https://doi.org/10.56294/saludcyt2024728.

González Salas R, Vidal Del Río MM, Medina Valencia MP, Jaramillo López MG. Bibliographic review on hepatopancreatic microsporidiosis in white shrimp penaeus vannamei: a current emerging disease. Salud, Ciencia y Tecnología 2023;3:601. https://doi.org/10.56294/saludcyt2023601.

Peláez Yáñez LA, Orraca Castillo O, García García M, Lugo Hernández A, Lorenzo Rodriguez MA, Vitón Castillo AA. Chronic mucocutaneous candidiasis: case report. Salud, Ciencia y Tecnología 2024;4. https://doi.org/10.56294/saludcyt2024.1368.

Aguiar Muñoz NR, Yauli Flores CF. Current Perspectives on Antifungal Resistance: Focus on Opportunistic Mycoses. Salud, Ciencia y Tecnología 2024;4:1064. https://doi.org/10.56294/saludcyt20241064.

Rodríguez Plasencia A, Ortiz Vásquez GE, Donoso Noroña RF, Gómez Martínez N. Impact of antimicrobial resistance in critically ill patients in the intensive care unit. Salud, Ciencia y Tecnología 2023;3:648. https://doi.org/10.56294/saludcyt2023648.

Zambrano Zambrano DT, Tabares Rosero LG. Influence of the use of psychotropic drugs on the increase of Escherichia coli resistance. Salud, Ciencia y Tecnología 2024;4:701. https://doi.org/10.56294/saludcyt2024701.

Bravo J. Candida haemulonii: causa infrecuente de peritonitis asociada a diálisis peritoneal. Revista Infection 2018;22. http://www.scielo.org.co/scielo.php?pid=S0123-93922018000100058&script=sci_arttext.

Muthular M, Passero P, Bálsamo F. Efecto inhibitorio Efecto inhibitorio del dietilestilbestrol sobre aislamientos clínicos de Candida albicans sensibles y resistentes a los azoles. Revista Iberoamericana de Micologia 2019;36. https://www.sciencedirect.com/science/article/abs/pii/S1130140619300312.

Pristov K, Ghannoum M. Resistance of Candida to azoles and echinocandins worldwide. Science Direct 2019;25. https://www.sciencedirect.com/science/article/pii/S1198743X19301491.

Spampinato C, Leonardi D. Candida infections, causes, targets, and resistance mechanisms: traditional and alternative antifungal agents. Online Librery 2013. https://onlinelibrary.wiley.com/doi/full/10.1155/2013/204237.

López-Ávila K, Dzul-Rosado K, Lugo-Caballero C. Mecanismos de resistencia antifúngica de los azoles en Candida albicans. Una revisión. Scielo 2016;27. https://www.scielo.org.mx/pdf/revbiomed/v27n3/2007-8447-revbiomed-27-03-127.pdf.

González Ortega N. Candida auris, nuevo hongo patógeno multirresistente Trabajo de Fin de Grado, Grado en Farmacia Tutor: José Manuel de la Rosa Reyes Facultad La Laguna Área de Microbiología. RIULL 2020. https://riull.ull.es/xmlui/handle/915/24042.

Castillo-Martínez N, Mouriño-Pérez R, Cornejo-Bravo J. Factors related to oral candidiasis in HIV children and adolescents, species characterization and antifungal susceptibility. Revista Chilena de Infectologia 2018;35. https://europepmc.org/article/med/30534924.

Du H, Bing J, Hu T, Ennis C, Nobile C. Candida auris: Epidemiology, biology, antifungal resistance, and virulence. PLoS Pathog 2020;16. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008921.

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Published

2025-01-01

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Original

How to Cite

1.
Godoy M, Brusca MI. Oral candidiasis: differentiation of Candida spp strains and antifungal treatments. Interamerican Journal of Health Sciences [Internet]. 2025 Jan. 1 [cited 2024 Dec. 14];5:249. Available from: https://ijhsc.uai.edu.ar/index.php/ijhsc/article/view/249