The utility of lidocaine in neonatal conviction syndrome:a systematic review

Abstract

Introduction: lidocaine is a drug belonging to the local anesthetics, it is rapidly distributed in the body and
metabolized in the liver. At commonly recommended doses, the therapeutic index of lidocaine remains very high
and plasma concentrations remain largely below neurotoxic, cardiotoxic and other thresholds. It is used during
various medical procedures, and in the nervous system it acts by binding to a specific site which is the sodium
channel receptor of the neural membrane and blocking the passage of ions.
Objective: to determine the potential usefulness of lidocaine in neonates with convulsive syndrome.
Methods: in the present systematic review we tried to provide an answer and conducted a literature search
through pubmed and others to analyze the usefulness of lidocaine in neonatal convulsive syndrome and its
potential benefit.
Results: after applying the inclusion and exclusion criteria, we will be able to identify the groups of neonates at
higher risk and the efficacy of lidocaine treatment.
Conclusions: lidocaine is the third drug used in neonatal convulsive syndrome for maintenance where they
receive it in continuous infusion, being effective in suppressing electro-clinical crises. Excessive doses of
lidocaine should be avoided since it can produce convulsions and other adverse effects in children