The utility of lidocaine in neonatal conviction syndrome:a systematic review

Authors

DOI:

https://doi.org/10.59471/ijhsc2024178

Keywords:

Lidocaine, Anticonvulsants, Lidocaine Utility, Seizure Symdrome, Neonatal

Abstract

Introduction: lidocaine is a drug belonging to the local anesthetics, it is rapidly distributed in the body and
metabolized in the liver. At commonly recommended doses, the therapeutic index of lidocaine remains very high
and plasma concentrations remain largely below neurotoxic, cardiotoxic and other thresholds. It is used during
various medical procedures, and in the nervous system it acts by binding to a specific site which is the sodium
channel receptor of the neural membrane and blocking the passage of ions.
Objective: to determine the potential usefulness of lidocaine in neonates with convulsive syndrome.
Methods: in the present systematic review we tried to provide an answer and conducted a literature search
through pubmed and others to analyze the usefulness of lidocaine in neonatal convulsive syndrome and its
potential benefit.
Results: after applying the inclusion and exclusion criteria, we will be able to identify the groups of neonates at
higher risk and the efficacy of lidocaine treatment.
Conclusions: lidocaine is the third drug used in neonatal convulsive syndrome for maintenance where they
receive it in continuous infusion, being effective in suppressing electro-clinical crises. Excessive doses of
lidocaine should be avoided since it can produce convulsions and other adverse effects in children

References

Gerardo Ochoa-Anaya, Claudia

Patricia Aguirre-Ibarra, Montserrat Franco-Cabrera. Lidocaína: aspectos generales y nuevas implicaciones en la inflamación. 2017;(3).

Castelló JC, Gómez LA, Villar GV, Serrano MM. Convulsiones neonatales. Protocolo de manejo.

Lidocaína | Asociación Española de Pediatría [Internet]. [citado 3 de agosto de 2023]. Disponible en: https://www.aeped.es/comitemedicamentos/pediamecum/lidocaina

Glass HC, Pham TN, Danielsen B, Towner D, Glidden D, Wu YW.

Antenatal and Intrapartum Risk

Factors for Seizures in Term

Newborns: A Population-Based Study,

California 1998-2002. The Journal of Pediatrics. 1 de enero de 2009;154(1):24-28.e1.

Alonso García B, Samper Villagrasa MP. Crisis convulsivas en el neonato. Zaragoza: Universidad de Zaragoza; 2019.

REVISION BIBLIOGRÁFICA

CONVULCIONES NEONATALES.pdf

[Internet]. [citado 3 de agosto de 2023]. Disponible en: https://www.kerwa.ucr.ac.cr/bitstream/ handle/10669/79937/REVISION%20BI BLIOGR%c3%81FICA%20CONVULCI ONES%20%20NEONATALES.pdf?se quence=1&isAllowed=y

Troncoso A L, Menéndez G P, Hernández Ch M. Convulsiones neonatales: diagnóstico y manejo.

Revista chilena de pediatría. mayo de 2001;72(3):190-8.

Feld DV. CONVULSIONES NEONATALES. Normas de

evaluación, diagnóstico y tratamiento.

a9_1_tr_convulsionesneonatales.pdf [Internet]. [citado 2 de agosto de 2023]. Disponible en:

https://www.revistachilenadeepilepsia. cl/revistas/revista_2008/a9_1_tr_conv ulsionesneonatales.pdf

a9_1_tr_convulsionesneonatales.pdf [Internet]. [citado 3 de agosto de 2023]. Disponible en: https://www.revistachilenadeepilepsia. cl/revistas/revista_2008/a9_1_tr_conv ulsionesneonatales.pdf

Evans D, Levene M. Neonatal seizures. Arch Dis Child Fetal Neonatal Ed. enero de 1998;78(1):F70-5.

Barba DJP. EVALUACIÓN Y MANEJO DEL NIÑO CON LESION NEUROLÓGICA GRAVE.

Published

2024-03-05

Issue

Section

Review

How to Cite

1.
Milange JM, Estrin MA. The utility of lidocaine in neonatal conviction syndrome:a systematic review. Interamerican Journal of Health Sciences [Internet]. 2024 Mar. 5 [cited 2024 Nov. 3];4:178. Available from: https://ijhsc.uai.edu.ar/index.php/ijhsc/article/view/201