Epigenetics in Periodontics

Authors

DOI:

https://doi.org/10.59471/ijhsc2024114

Keywords:

Epigenetics in Periodontitis, Periodontitis, Epigenetics

Abstract

Background: periodontitis is a pathology characterized by the destruction of dental support tissue, in its worst scenario it can cause the loss of the dental organ; Its etiological factor is periodontopathogenic bacteria, however, this is a multifactorial disease, that is, not only environmental factors are involved but also genetic factors that are responsible for modulating the progression of periodontal disease. Not all patients will have the same susceptibility to developing Periodontitis since basically this will depend on the immunity of the host and its genetic code. Objective: to present the epigenetic mechanisms that have been applied in the field of Periodontics in order that these studies lead to the discovery of new regulatory treatments that offer to be an alternative to control inflammation in Periodontitis, that is, based on the findings already exposed in the future it is estimated that they can be translated into clinical practice. Methods: this article has prepared a compilation and analysis of the literature using the database of Scopus, Pubmed, EBSCO and Cochrane. We included experimental trials, case-control studies, review studies and meta-analyses. Results: Several studies have been presented that facilitate the understanding of the epigenetic mechanisms involved in pathological processes, such as specific biomarkers for certain diseases and genes that regulate inflammatory processes; In addition, it was mentioned that there are inhibitory molecules that allow the modulation of the inflammatory process of the host

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Published

2024-07-11

Issue

Section

Original

How to Cite

1.
María Eugenia Paredes Herrera MEPH, Miranda Rosero OD, Tobar Peñaherrera AN, Salazar Durán M de los Ángeles. Epigenetics in Periodontics. Interamerican Journal of Health Sciences [Internet]. 2024 Jul. 11 [cited 2024 Dec. 7];4:114. Available from: https://ijhsc.uai.edu.ar/index.php/ijhsc/article/view/114